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It is found mostly bound to plasma proteins, about 85%. Analogues of mirtazapine include mianserin, setiptiline, and aptazapine.It is metabolized primarily in the liver by demethylation and hydroxylation via cytochrome P450 enzymes, CYP1A2, CYP2D6, CYP3A4. A chemical synthesis of mirtazapine has been published.Mirtazapine also has some veterinary use in cats and dogs.Mirtazapine is sometimes prescribed as an appetite stimulant for cats or dogs experiencing anorexia due to medical conditions such as chronic kidney disease.
receptors leading to a host of negative changes and side effects, the most prominent of which including anorexia, insomnia, sexual dysfunction (loss of libido and anorgasmia), nausea, and diarrhea, among others.
In this case take the smaller dose in the morning and the higher dose before you go to bed. The usual starting dose for mirtazapine is 15 to 30mg a day. If you have problems with your liver or kidneys your doctor might prescribe a lower dose.